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Inventi Impact: Genetics

Articles

  • Inventi:hgt/26601/18
    The Differential Expression of Core Genes in Nucleotide Excision Repair Pathway Indicates\nColorectal Carcinogenesis and Prognosis
    01-Jan-1970 Research 2018 : October - December
    Jingwei Liu, Hao Li, Liping Sun, Xue Feng, Zhenning Wang, Yuan Yuan, Chengzhong Xing

    Background. Nucleotide excision repair (NER) plays a critical role in maintaining genome integrity. This study aimed to investigate\nthe expression of NER genes and their associations with colorectal cancer (CRC) development. Method. Expressions of NER genes\nin CRC and normal tissues were analysed by ONCOMINE. The Cancer Genome Atlas (TCGA) data were downloaded to explore\nrelationship of NER expression with clinicopathological parameters and survival of CRC. Results. ERCC1, ERCC2, ERCC5, and\nDDB2 were upregulated while ERCC4 was downregulated in CRC. For colon cancer, high ERCC3 expression was related to better T\nstage; ERCC5 expression indicated deeper T stage and distant metastasis; DDB2 expression suggested earlier TNM stage. For rectal\ncancer, ERCC2 expression correlated with favourable T stage; XPA expression predicted worse TNM stage. ERCC2 expression was\nassociated with worse overall survival (OS) in colon cancer (HR = 1.53,

    How to Cite this Article
    Jingwei Liu, Hao Li, Liping Sun, et al., â??The\nDifferential Expression of Core Genes in Nucleotide Excision\nRepair Pathway Indicates Colorectal Carcinogenesis and\nPrognosis,â? BioMed Research International, vol. 2018, Article ID\n9651320, 10 pages, 2018. https://\ndoi.org/10.1155/2018/9651320, https://creativecommons.org/\nlicenses/by/4.0/.
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